TOKYO (Reuters) - Exxon Mobil plans to sell a large part of its 50 percent stake in TonenGeneral Sekiyu KK back to its Japanese refining partner in a deal that could be worth about 300 billion yen ($3.9 billion), and will make an announcement as early as Monday, four sources with direct knowledge of the matter said.
DAVOS, Switzerland (Reuters) - Europeans are making progress to overcome the euro zone crisis but need to do more to boost their financial firewall, International Monetary Fund Managing Director Christine Lagarde said on Saturday, adding that the IMF is also ready to help.
(Reuters) - Rupert Murdoch's News Corp is in "serious talks" to poach veteran Bloomberg LP executive Lex Fenwick to run its Dow Jones publishing business, which houses the Wall Street Journal, according to two people familiar with the discussions.
Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) in the majority of people with grade 2 and 3 gliomas is associated with elevated levels of 2-hydroxyglutarate (2HG) within the tumor. As harboring IDH1 or IDH2 mutations confers a considerable survival benefit in these individuals, there has been considerable interest in studying this metabolite as a potential biomarker. Here, Changho Choi et al. report the successful noninvasive detection of 2HG in 30 subjects with gliomas using a proton magnetic resonance spectroscopy approach.
This report uncovers a direct link between cancer-driving inflammation and DNA methylation by showing that PGE2 regulates the expression of DNA methylases, resulting in silencing of tumor-suppressor genes. The authors suggest that DNA methylation is an important component of the pathogenic effect of inflammatory signaling in colorectal cancer.
